Human Sera
Cayman Chemical 2deoxy2fluoroDGlucose 100mg
An ER modulator acts as an ER antagonist in humans sheep and rabbits and an ER agonist in rats inhibits E2 binding in isolated rabbit uterus at 0.34 UM decreases E2-induced inhibition of FSH secretion in primary sheep pituitary cells in a concentration-dependent manner inhibits spermatogenesis and decreases serum LH and testosterone levels in intact or castrated rats at 0.25 and 0.5 mg/animal
Cayman Chemical TerbuthylazIn 50mg
An FFAR2/GPR43 positive allosteric modulator (EC50 0.42 UM for [35S]GTPYS binding to 293 T-REx cell membranes expressing the human receptor) selectively induces ERK1/2 phosphorylation in 293 T-REx cells expressing human FFAR2 but not FFAR1 or FFAR3
Cayman Chemical 7Ethoxy4 trIfluoromethylc 50mg
Immunogen A peptide corresponding to histone H3K36M mutant Host Rabbit Cross Reactivity (-) Wild-type histone H3 Species Reactivity ( ) Histone H3K36M mutant Applications ELISA IHC WB A probe for immunochemical detection of the H3K36M mutant
Cayman Chemical 22 S 23 S-HomobrasInolIde 50mg
A macrolide antibiotic active against E. coli S. aureus and B. subtilis (MIC99s 50-60 90-100 and 25-30 UM respectively)
Cayman Chemical GadoterIdol 100mg
A histamine H3 receptor agonist (KI 0.4 nM in SK-N-MC cell membranes expressing the human receptor) selective for histamine H3 over H1 and H2 receptors in CHO cell membranes expressing the guinea pig and human receptors respectively (Kis 16 M for both) but also agonizes H4 receptors (KI 9 nM in SK-N-MC cell membranes expressing the human receptor) decreases hypothalamic histamine release in anesthetized rats at 5 mg/kg decreases flinching in the formalin test in rats at 5 and 30 mg/kg and inhibits formalin-induced paw edema at 30 mg/kg
Cayman Chemical FluorescamIn 50mg
A fungal metabolite inhibits HIV-1 Tat transactivation in a cell-based assay (IC50 15.8 UM) cytotoxic to HeLa KB and NCI H187 cancer cells (IC50s 8.3 9 and 5.1 UM respectively) active against C. albicans (MIC 4 mM)
Cayman Chemical 7-MethylxnthIn 100mg
A depsidone active against E. faecalis H. influenzae M. catarrhalis S. aureus and S. pneumoniae (MICs 8 32 1 128 and 64 Ug/ml respectively) inhibits PheRS isolated from P. aeruginosa (IC50 42 UM) inhibits OATP1B1 and OATP1B3 (Kis 0.08 and 1.84 UM respectively in CHO cells expressing the human transporters)
Cayman Chemical Forchlorfenuron 100mg
A building block has been used in the synthesis of carcinolytic compounds
Cayman Chemical CIcloprofen 100mg
A histamine H3 and H4 receptor agonist (Kis 0.3 and 2.7 nM respectively in radioligand binding assays) selective for histamine H3 and H4 receptors over H1 and H2 receptors when used at 100 UM as well as 5-HT3 (Ki 240 nM) reduces potassium-induced increases in histamine levels in isolated rat cerebral cortex slices (EC50 2.8 nM) increases scratching in mice (ED50 0.9 Umol)
Cayman Chemical TrIacontnoIc AcId 100mg
A building block has been used in the synthesis of 13C6-labeled naphthalenes and polychlorinated biphenyls
Cayman Chemical Myrislignan 50mg
An internal standard for the quantification of myristic acid by GC- or LC-MS
Cayman Chemical Phellandrene 100mg
A nonpeptide NK3 antagonist (Ki 1 nM) selective for NK3 over NK1 and NK2 receptors (Kis 144 and 100000 nM respectively in CHO cells expressing recombinant human receptors) inhibits neurokinin B-induced calcium mobilization in HEK293 cells expressing human NK3 receptors (IC50 16.6 nM) inhibits senktide-induced contractions in isolated rabbit iris sphincter muscle (pD2 9.1) reduces senktide-induced head shakes and tail whips in mice from 5-20 mg/kg inhibits senktide-induced wet-dog shakes increases extracellular dopamine and norepinephrine in the medial prefrontal cortex and attenuates haloperidol-induced increases in nucleus accumbens dopamine levels in guinea pigs
Cayman Chemical DIhydroxyaceton PhosphATm 50mg
A sesquiterpene with diverse biological activities inhibits lipid peroxidation in rat hepatic microsomes (IC50 9.8 M) scavenges hydroxyl and DPPH radicals in cell-free assays inhibits LPS-induced nitric oxide production in RAW 264.7 cells (EC50 10.1 M) cytotoxic to RAW 264.7 cells (CC50s 29.8 and 30.8 M in the presence and absence respectively of LPS) cytotoxic to N2a neuroblastoma cells and primary rat neurons inhibits paracetamol-induced decreases in hepatic GSH in rats at 250 mg/kg
Cayman Chemical LavendustIn B 50mg
A peptide hormone increases crypt cell proliferation total weight of the small bowel and mucosal thickness of the proximal and distal jejunum and ileum in mice (43 75 g twice a day) increases jejunal mucosal surface area and reduces resection-induced decreases in SGLT-1 and GLUT-2 transporter abundance as well as resection-induced increases in blood glucose levels and body fat loss in a rat model of distal bowel resection