Human Sera
Cayman Chemical EuphorbIasteroId 100mg
A tricyclic diterpene; inhibits EArly-stage adipogenesis of 3T3-L1 cells at 25 and 50 µM; inhibits proliferation of HL-60 cells in a concentration-dependent manner, as well as induces apoptosis and increases the expression of Fas and Fas ligand (FasL) and the activity of caspase-3 and caspase-8 in HL-60 cells; increases P-glycoprotein activity, reverses multi-drug resistance, and restores cytotoxicity of vinblastine, paclitaxel, and doxorubicin to MES/SA/Dx5 sarcoma cells
Cayman Chemical PurpurogalIn 50mg
A phenol; active against a range of bacteria (MICs = 11-110 UG/ml) and P. falciparum strain FCB1 clone NC-1 (IC50 = 55 µM); scavenges DPPH radicals in a cell-free assay and reduces hydrogen peroxide and radiation-induced production of ROS in HaCaT keratinocytes at 2, 5, and 10 µM; inhibits the activity of EGFR, GST, prolyl endopeptidase, and glyoxalase I (IC50s = 27.5, 8, 16, and 50 µM, respectively), as well as COMT (Ki = 0.074 µM), in cell-free assays
Cayman Chemical DorIpenmhydrate 50mg
A broad-spectrum antibiotic; is active against Gram-negative and Gram-positive bacteria, including S. aureus, S. pneumoniae, E. coli, and K. pneumoniae (MICs = 0.03-0.06, 0.016-0.06, P. aeruginosa respiratory tract infection at 100 mg/kg per day
Cayman Chemical RIfapentIn 100mg
A long-lasting rifamycin antibiotic that is effective against Mycobacterium species, including M. tuberculosis as well as experimental infections caused by S. aureus, S. pyogenes group A, S. pneumoniae, and K. pneumoniae
Cayman Chemical GlucosylceramIdeplnt 50mg
A mixture of glucosylceramides isolated from soy; levels decrease during cold acclimatization in plants; involved in the regulation of virulence in fungi and act as elicitors in plants, stimulating plant defense mechanisms; increased levels are associated with obesity-induced insulin resistance in mice and with neuronal deficits observed in neuronopathic Gaucher disease
Cayman Chemical HalcInonIde 50mg
A synthetic glucocorticoid with anti-inflammatory properties; inhibits edema by 55% in a RPA test in rabbit when administered topically (0.1% w/w); inhibits edema by 70.1% and 88.0% in croton oil-induced and PCA tests, respectively, in rat (topical, 0.1% w/w); in vivo application (0.1% w/w) to the abraded surface of cecum in rats inhibits leukocyte adhesion (43.3% incidence versus 100% for controls) and lowers the total number of intraperitoneal leukocytes from 270 million to 121 million 3 days post surgery; acts as an agonist at the Smo receptor (EC50 = 1,100 nM)
Cayman Chemical Pnax gInseng PnaxadIol 50mg
A triterpenoid sapogenin; inhibits the growth of HepG2, A549, MCF-7, and HCT116 cancer cells (IC50s = 63.20, 40.88, 61.96, and 92.53 µM, respectively); reduces tumor growth in an HCT116 mouse xenograft model at 30 mg/kg; inhibits HBV DNA replication in HepG 2.2.15 cells (IC50 = 148.15 µM); decreases the escape latency in the MWM in an APP/PS1 mouse model of Alzheimer’s disease at 50 mg/kg
Cayman Chemical CarbIdopahydrate 100mg
A dopamine decarboxylase inhibitor; inhibits conversion of L-DOPA to dopamine in the periphery; increases the plasma concentration of L-DOPA by 186% and prolongs the half-life in plasma by 48% and skeletal muscle extracellular fluid by 66% in dog when administered at a dose of 100 mg/kg; potentiates the activity of AhR; inhibits proliferation of pancreatic cancer cells in vitro and tumor growth in vivo
Cayman Chemical Cabergoln 50mg
A potent and selective dopamine D2 receptor agonist (Kis = 0.912 and 6,935 nM for D2 and D1 receptors, respectively, in rat striatum); inhibits PRL secretion in and growth of rat pituitary tumor cells in a concentration-dependent manner; suppresses the mTOR signaling pathway in a time-dependent manner and induces autophagy and cell death in MMQ and GH3 rat pituitary cells; stimulates motor activity and decreases dyskinesias in a monkey model of MPTP-induced Parkinson's disease when administered at a dose of 0.25 mg/kg
Cayman Chemical 4NItrophenyl DXylopyrnos 100mg
A chromogenic β-xylosidase substrate; upon hydrolysis by β-xylosidase, 4-nitrophenol is released, which can be quantified by colorimetric detection at 405 nm as a measure of β-xylosidase activity
Cayman Chemical MonacylglycRol lpase InHB 50mg
Selectively and reversibly blocks MAGL activity (IC50s = 0.18 and 59 µM for MAGL and FAAH in mouse brain, respectively); does not inhibit ABHD6, ABHD12, CB1, or CB2 receptors (Kis > 10 µM); used to ameliorate disease progression in a mouse model of multiple sclerosis
Cayman Chemical ArtemIsInIc AcId 100mg
A sesquiterpene; decreases triglyceride levels and GPDH activity in hAMSCs; inhibits adipocyte differentiation at 200 µM; decreases C/EBPα and HMG-CoA reductase mRNA expression and inhibits cholesterol synthesis and melanogenesis in human epidermal melanocytes
Cayman Chemical Otospon astatus upaton 50mg
A flavonoid with diverse biological activities; inhibits the growth of HeLa, MK-1, and B16/F10 tumor cells (GI50s = 15, 58, and 44 µM, respectively); active against T. cruzi epimastigotes and trypomastigotes (IC50s = 0.2 and 61.8 UG/ml, respectively); induces vasorelaxation in isolated rat thoracic aortic rings precontracted with phenylephrine (pD2 = 6.66); reduces nuclear translocation of NF-κB and STAT1α in J774 murine macrophages at 10 and 100 µM; reduces paw edema in a mouse model of carrageenan-induced paw inflammation at 50 mg/kg
Cayman Chemical AOD-9604acetate 50mg
A synthetic lipolytic peptide; decreases body weight, epididymal adipose tissue mass, and brown adipose tissue weight in ob/ob mice at 250 UG/kg per day; enhances cartilage regeneration in a rabbit model of collagenase-induced knee osteoarthritis
Cayman Chemical 2Omethyl PAF C18hydrAT 50mg
A synthetic PAF analog which contains an ether-linked methyl group at the sn-2 position; decreases plasma membrane fluidity, inhibits tumor cell invasiveness, and causes the release of large quantities of NO by a pathway involving activation of NOS