Human Sera
Cayman Chemical UmIfenovIrhydrochlorIde 100mg
A broad-spectrum antiviral agent; inhibits the replication of H5N1 influenza (IC50 = 30 UG/ml) and SARS-CoV-2 in vitro (IC50 = 3.537 µM); inhibits entry of HCV pseudoparticles in Huh7 cells (IC50 = 6 UG/ml); reduces the formation of influenza-induced lung lesions in ferrets at 45 mg/kg
Cayman Chemical TomatIdInhydrochlorIde 50mg
A steroidal alkaloid with diverse biological activities; suppresses NF-κB signaling as well as iNOS and COX-2 expression in LPS-stimulated macrophages; inhibits acid sphingomyelinase activity at 10 mM; preferentially blocks replication of S. aureus variants that are pathogenic in cystic fibrosis over normal strains (MICs = 0.12 and >16 UG/ml, respectively); prevents skeletal muscle atrophy associated with fasting or spinal cord injury in mice; has been used as a negative control for cyclopamine in studies involving signaling mediated by the hedgehog pathway
Cayman Chemical TazobactamsodIum salt 100mg
A β-lactamase inhibitor; inhibits Ambler class A serine penicillinases and class C cephalosporinases, including TEM-1, SHV-1, and P99 (IC50s = 97, 150, and 8.5 nM) and the class D oxacillinase OXA-2 (IC50 = 10 nM); active against Gram-positive (MIC90s = 2-128 UG/ml) and Gram-negative bacteria (MIC90s = 4-128 UG/ml) when used in combination with piperacillin; potentiates the activity of ceftolozane against Enterobacteriaceae in a neutropenic mouse model of thigh infection
Cayman Chemical ClorgylInhydrochlorIde 50mg
A potent MAO inhibitor that preferentially targets MAO-A over MAO-B (Kis = 0.054 and 58 µM, respectively); also inhibits the sigma receptor σ1 on Jurkat human T lymphocyte cells (IC50 = 31 nM)
Cayman Chemical LIthospermosIde 50mg
A nitrile glucoside with antitumor activity; inhibits TPA-induced activation of EBV-EA in Raji cells
Cayman Chemical CarteololhydrochlorIde 50mg
A β-adrenergic receptor antagonist (Kd = 13 nM); blocks isoproterenol-induced increases in heart rate, contractile force, and blood pressure in vagotomized dogs (ED50s = 2.3, 3.1, and 1.8 UG/kg, respectively); the (R) and (S)-enantiomers EAch reduce intraocular pressure in rabbits (1% solution)
Cayman Chemical DIoctnoyl Glycol 50mg
A DGK inhibitor (Ki = 58 μM); reduces basal and thrombin-stimulated phosphatidic acid levels in washed isolated human platelets at 30, 100, and 500 μM
Cayman Chemical R4AmIno3hydroxybutyrIc 100mg
A GABA receptor modulator; binds to GABAA and GABAB receptors (IC50s = 1 and 0.35 µM, respectively); inhibits GABA uptake in rat brain synaptosomes (IC50 = 67 µM); induces currents in a patch-clamp assay using Xenopus oocytes expressing human GABAC (EC50 = 19 µM); inhibits electrical discharges in the amygdala in a cat model of N-amidinobenzamide-induced seizures at 20 mg/animal
Cayman Chemical 1H 1H 2H 2HPRfluorodecnsu 50mg
A polyfluoroalkyl substance; has been found as a contaminant in sea and river water
Cayman Chemical DaclatsvIr 100mg
An NS5A inhibitor (Kds = 8 and 210 nM for the NS5A33-202 and NS5A26-202 residues of HCV genotype 1b, respectively); potently inhibits HCV replication in multiple HCV replicon genotypes (EC50s = 9-146 pM) with the highest potency in genotypes 1b and 4a (EC50s = 9 and 12 pM, respectively); disrupts NS5A subcellular localization when used at a concentration of 1 nM; inhibits HCV RNA synthesis and virion assembly and secretion when used at a concentration of 1 nM; inhibits OAT1B1 and OAT1B3 (IC50s = 1.5 and 3.27 µM, respectively)
Cayman Chemical ResmInostathydrochlorIde 50mg
An orally bioavailable inhibitor of HDAC1, HDAC3, and HDAC6 (IC50s = 43-72 nM), resulting in hyperacetylation of histone H4 in multiple myeloma cells; abrogates cell growth and strongly induces apoptosis in multiple myeloma cells (IC50s = 2.5-3 µM); dose-dependently inhibits HDAC activity in vivo
Cayman Chemical Nacetyl Sulfamethoxazole 100mg
A urinary metabolite of sulfamethoxazole, an antibiotic with antiviral activity
Cayman Chemical IonIzable LIpId 4 50mg
An ionizable cationic lipid (pKa = 6.1) and hydrogen peroxide-induced rearrangement product of the cationic lipid CA-lipid 5; CALNPs containing CA-lipid 5 and encapsulating siRNA against EGFP undergo hydrogen peroxide-induced removal of the phenylboronic acid groups from CA-lipid 5 in MCF-7 cells in vitro, generating ionizable lipid 4-containing LNPs with reduced positive charges at physiological pH, facilitating intracellular siRNA release and gene silencing; LNPs containing ionizable lipid 4 and encapsulating siRNA against PLK1 reduce tumor volume in an MCF-7 mouse xenograft model
Cayman Chemical SARACATINIB 50MG
A dual inhibitor of c-Src and Abl (IC50 = 2.7 and 30 nM, respectively); less effectively inhibits other kinases; blocks cell motility, migration, adhesion, invasion, proliferation, differentiation, and survival; reduces osteoclast bone resorption
Cayman Chemical GnglIosIde GM1bovInam 50mg
A mixture of ganglioside GM1 species isolated from bovine brain with primarily C18:0 acyl chain lengths; interacts with other proteins to increase calcium influx, affecting various calcium-dependent processes, including inducing neuronal outgrowth during differentiation; acts as a receptor for cholera toxin and the heat-labile enterotoxin from E. coli; induces apoptosis in activated T cells; found at higher levels on T cells isolated from patients with RCC; levels are decreased in the substantia nigra pars compacta in postmortem brain from patients with Parkinson’s disease; accumulates in neurons in ganglioside GM1 gangliosidosis